Bioneem has been found to be compatible with most commonly used fungicides, insecticides, and fertilisers. Physical compatibility should first be checked by using the current proportions of products in a small test jar. Growers should then test tank mix combinations for phytotoxicity on a sample of the plant or crops prior to use. Do not mix with oxidising agents such as bleach, or strong acids and bases as they will destabilise the product.

Spray solutions should be used within a few hours of preparation for maximum effectiveness. Do not store diluted solution for later use.

Neem is suitable for indoor and outdoor use. Shake well before use. Bioneem does not have an instant knockdown effect, it normally takes 3-7 days for death to occur, however damage is reduced almost immediately due to the anti- feedant effect of the product. Apply in early to mid-morning or late afternoon. Do not apply in temperatures above 30°C.